Research at Wu Lab

Dr June Wu

Dr. Wu’s research focuses on Vascular Anomalies, which include congenital lesions that originate from the vascular system, as well as overgrowth syndromes associated with vascular anomalies. Dr. Wu’s research program focuses on translational research, correlating genetic variants in these diseases to their therapeutic responses, with the goal of bringing novel therapeutics to this patient population with no cure and limited treatment options.

Dr. Wu’s lab collaborates closely with Dr. Carrie Shawber’s laboratory (please hyperlink). Dr. Shawber is an international renowned vascular developmental biologist with specific interest in lymphatic development as well as congenital and progressive disorders of the lymphatic system.

Recent discoveries and accomplishments at the Wu lab (in collaboration with Dr. Carrie Shawber):

  • One of the largest biobanks of vascular anomalies tissues
  • Propranolol mechanisms in infantile hemangioma
  • Propranolol use in congenital lymphatic anomalies (congenital chylothorax)
  • Propranolol use in postoperative chylothorax in congenital heart disease
  • Discovery of pathologic proteostasis defects in slow-flow vascular malformations
  • Discovery of proteasome inhibitors (# CU20315 PCT U.S. Patent Application No. 63/024,670)

Awards by presents and past members:

  • 2012: Chairman’s Career Development Award (June Wu)
  • 2012: Best Experimental Paper, 2012, Plastic & Reconstructive Surgery (Alvin Wong)
  • 2013: Irving Scholar Award (June Wu)
  • 2014: Gingrass Award (Naikhoba Munabi)
  • 2015: Crikelair Award (Alison Kitajewski)

Present and Past Funding:

  • 2005-2006: Juvenile Diabetes Research Foundation (co-PI)
  • 2007-2008: Forde Junior Faculty Research Grant (PI)
  • 2010-2011: Irving Center for Clinical Research (CTO/CTSA) Pilot Award (PI)
  • 2010-2011: Plastic Surgery Education Foundation Pilot Research Grant (PI)
  • 2010-2015: NIH/NHLBI K08 (PI)
  • 2012-2013: Chairman’s Career Development Award (PI)
  • 2013-2014: NIH/NIBBB R21 (Collaborator)
  • 2013-2016: Irving Scholar Award (PI)
  • 2017: GLA/GSD Pilot Grant (co-I)
  • 2019-2022: DOD Peer Reviewed Medical Research Program (Partnering PI)
  • 2022-2023: Lymphatic Malformation Institute Pilot Grant (co-I)
  • 2022-2026: NIH/NHLBI (Multiple PI)

Complete List peer-reviewed Publications in My Bibliography: