News

What's New in the Department of Surgery

New Cocktail Boosts Recovery from Hepatitis C

For someone with liver disease, a cocktail is normally a forbidden luxury. But in some cases, it may be just what the doctor ordered. Two recently approved medications are now being combined with traditional treatments to form a powerful new drug cocktail, improving the outcomes among patients with this challenging disease.
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Funded by the National Institute of Neurological Disorders and Stroke (NINDS), this international, multicenter clinical study is evaluating the effectiveness of thymus gland removal (thymectomy) as a treatment for myasthenia gravis. The trial commenced in 2006 and has an expected completion date of August 2010. Joshua Sonett, MD, Chief of Thoracic Surgery at Columbia, is the surgeon for the Columbia site. Alfred Jaretzki, MD, Professor Emeritus of Clinical Surgery at Columbia is a member of the trial's Executive Committee, and in this role is an author on two articles regarding the study.
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Preserving organs on ice prior to transplantation, an approach known as cold storage or CS, has been the standard practice in liver transplant for 20 years. Now there is new evidence that a technique called hypothermic machine perfusion (HMP) may offer an improvement, according to the first-ever study comparing the impact of the two techniques on transplant outcomes. The phase I study was carried out by Dr. James Guarrera and his colleagues at NewYork-Presbyterian Hospital/Columbia University Medical Center. Unlike cold storage, which Dr. Guarrera describes as a static technique, HMP dynamically simulates "aliveness" by providing a continuous flow of oxygen and key nutrients to the liver while diluting and removing toxins and waste products.
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