Researcher’s Profile

Michael D. Kluger, MD, MPH

Medical Director, Milstein Hospital 6HS Surgical Oncology Unit
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The objective of Dr. Kluger's research is to identify safe and effective innovations in surgical practices that will reduce morbidity in patients undergoing pancreatic and liver surgery, thereby improving survival.  Specific areas of current research include operative indications for indolent and pre-malignant pancreatic lesions, blood transfusion practices during pancreatic cancer surgery, safety and indications of laparoscopic liver surgery, and irreversible electroporation for locally advanced pancreatic cancer.

Publications: 
Peer Reviewed Publications Shakri AR, Zhong TJ, Ma W, Coker C, Kim S, Calluori S, Scholze H, Szabolcs M, Caffrey T, Grandgenett PM, Hollingsworth MA, Tanji K, Kluger MD, Miller G, Biswas AK, Acharyya S.  Upregulation of ZIP14 and Altered Zinc Homeostasis in Muscles in Pancreatic Cancer Cachexia.  Cancers.  Accepted for publication 12/12/19.   [Epub ahead of print]  PMID: 31861290. Leinwand JC, Taub RN, Chabot JA, Kluger MD. Two-Stage Cytoreductive Surgery and Intraperitoneal Chemotherapy for Diffuse Malignant Peritoneal Mesothelioma: Predictors of Overall Survival in an Intention-to-Treat Series.  Annals of Surgical Oncology.  2019 Dec 12.  [Epub ahead of print]  PMID: 31832913. Payen T, Oberstein P, Saharkhiz N, Palermo C, Sastra S, Han Y, Nabavizadeh A, Sagaliskiy I, Orelli B, Rosario V, Desrouilleres D, Remotti H, Kluger MD, Schrope B, Chabot J, Iuga A, Konofagou E, Olive K.  Noninvasive Young’s modulus visualization of fibrosis progression and delineation of pancreatic ductal adenocarcinoma (PDAC) tumors using Harmonic Motion Elastography (HME) in vivo.  Clinical Cancer Research.  2019 Dec 12.  [Epub ahead of print]  PMID: 31831559. Cui Y, Khanna LG, Saqi A, Crapanzano JP, Mitchell JM, Sethi A, Gonda TA, Kluger MD, Schrope BA, Allendorf J, Chabot JA, Poneros JM. The Role of Endoscopic Ultrasound-Guided Ki67 in The Management of Non-Functioning Pancreatic Neuroendocrine Tumors. Clin Endosc. 2019 Jul 15. [Epub ahead of print] PubMed PMID: 31302988. Sung S, Portillo A, Gonda T, Kluger MD, Tiscornia-Wasserman P.  Update on the risk stratification in the categories of the Papanicolaou Society of Cytopathology Reporting System for Pancreaticobiliary Cytology: 3-year prospective single institution experience.  Cancer Cytopathology.  2020; 128(1): 29-35.  PubMed PMID: 31722125. Letica-Kriegel AS, Leinwand JC, Sonett JR, Gorenstein LA, Taub RN, Chabot JA, Kluger MD. 50 Patients with Malignant Mesothelioma of Both the Pleura and Peritoneum: A Single-Institution Experience. Ann Surg Oncol. 2020;27(1):205-213.  PubMed PMID: 31065962. Jung W, Park T, Kim Y, Park H, Han Y, He J, Wolfgang CL, Blair A, Rashid MF, Kluger MD, Su GH, Chabot JA, Yang CY, Lou W, Valente R, Del Chiaro M, Shyr YM, Wang SE, van Huijgevoort NCM, Besselink MG, Yang Y, Kim H, Kwon W, Kim SW, Jang JY. Validation of a nomogram to predict the risk of cancer in patients with intraductal papillary mucinous neoplasm and main duct dilatation of 10 mm or less. Br J Surg. 2019; 106(13):1829-1836.  PubMed PMID: 31441048. Eyob B, Boeck MA, FaSiOen P, Cawich S, Kluger MD. Ensuring safe surgical care  across resource settings via surgical outcomes data & quality improvement initiatives. Int J Surg. 2019;72S:27-32. PubMed PMID: 31394278. Rashid MF, Jackson T, Morgan JA, Dwyer F, Schrope BA, Chabot JA, Kluger MD.  Dabigatran is safe for extended venous thromboembolism prophylaxis after surgery for pancreatic cancer.  Journal of Gastrointestinal Surgery. 2019; 23(6): 1166-1171.  PMID: 30187331 Elmously A, Gray KD, Michelassi F, Afaneh C, Kluger MD, Salemi A, Watkins AC, Pomp A.  Operating room attire policy and healthcare cost: favoring evidence over action for prevention of surgical site infections. Journal of the American College of Surgeons.  2019;228(1):98-106.  PMID: 30359824 Ecker BL, McMillan MT, Bassi C, Beane JD, Beckman RM, Behrman SW, Dickson EJ, Callery MP, Christein JD, Drebin JA, Hollis RH, House MG, Jamieson NB, Javed AA, Kent TS, Kluger MD, Kowalsky SJ, Maggino L, Malleo G, Valero V, Velu LKP, Watkins AA, Wolfgang CL, Zureikat AH, Vollmer CM.  Risk Factors and Mitigation Strategies for Pancreatic Fistula after Distal Pancreatectomy: Analysis of 2,026 Resections from the International, Multi-institution Distal Pancreatectomy Study Group.  Annals of Surgery.  2019;269(1):143-149.  PMID: 28857813 Woodland D, Cooper C, Rashid MF, Rosario V, Weyker P, Weintraub J, Bentley-Hibbert S, Kluger MD.  Routine Chest X-Ray is Unnecessary After Ultrasound-Guided Central Venous Line Placement in the Operating Room.  Journal of Critical Care.  2018;46:13-16.  PMID: 29627658 Rashid MF, Hecht EM, Steinman J, Kluger MD.  Irreversible Electroporation of Pancreatic Adenocarcinoma: A Primer for the Radiologist. Abdominal Radiology. 2018; 43(2): 457-466.  PMID: 29051982 Steinman J, Zaheer A, Kluger MD, Remotti H, Hecht EM.  Rare Pancreatic Tumors.  Abdominal Radiology. 2018; 43(2): 285-300. PMID: 29022085. Kluger MD, Rashid MF, Rosario VL, Schrope BA, Steinman J, Hecht EM, Chabot JA.  Resection of locally advanced pancreatic cancer without regression of arterial encasement after modern-era neoadjuvant therapy.  Journal of Gastrointestinal Surgery.  2018; 22(2):235-241. PMID: 28895032 Heller D, Chiuzan C, Taub RN, Leinwand J, Greene A, Bates G, Chabot JA, Kluger MD.  Recurrence of optimally treated diffuse malignant peritoneal mesothelioma with cytoreduction and heated intraperitoneal chemotherapy.  Annals of Surgical Oncology.  2017; 24(13): 3818-3824.  PMID: 29027138 Xu MM, Yin S, Siddiqui AA, Salem RR, Schrope B, Sethi A, Poneros JM, Gress FG, Genkinger JM, Do C, Brooks CA, Chabot JA, Kluger MD, Kowalski T, Loren DE, Aslanian H, Farrell JJ, Gonda TA. Comparison of the diagnostic accuracy of three current guidelines for the evaluation of asymptomatic pancreatic cystic neoplasms. Medicine (Baltimore). 2017;96(35):e7900. PMID: 28858107. Binhas M, Egbeola-Martial J, Kluger MD, Roudot-Thoraval F, Grimbert P.  Opioids and nonopioids for postoperative pain control in patients with chronic kidney disease.  J Opioid Manag. 2017;13(1):17-25.  PMID: 28345743 Najjar M, Taylor A, Agrawal S, Fojo T, Merkler AE, Rosenblum MK, Lennihan L, Kluger MD.  Anti-Hu paraneoplastic brainstem encephalitis caused by a pancreatic neuroendocrine tumor presenting with central hypoventilation.  Journal of Clinical Neuroscience.  2017;40:72-73.  PMID: 28256369 Hecht EM, Liu MZ, Prince MR, Jambawalikar S, Remotti HE, Weisberg SW, Garmon D, Lopez-Pintado S, Woo Y, Kluger MD, Chabot JA. Can diffusion-weighted imaging serve as a biomarker of fibrosis in pancreatic adenocarcinoma? J Magn Reson Imaging. 2017;46(2):393-402. PMID: 28152252 Yeh R, Steinman J, Luk L, Kluger MD, Hecht EM.  Imaging of pancreatic cancer: what the surgeon wants to know.  Clinical Imaging.  2016;7(42):203-217. PMID: 28110203 Leinwand JC, Chabot JA, Kluger MD.  Preventing recurrence of diffuse malignant peritoneal mesothelioma.  Expert Review of Anticancer Therapy. 2016;16(9):989-95. PMID: 27486718 Parekh M, Kluger MD, Griesemer A, Bentley-Hibbert S.  Regenerative liver surgeries: the alphabet soup of emerging techniques.  Abdominal Radiology. 2016;41(1):162-73.  PMID: 26830622   Kluger MD, Epelboym I, Schrope BA, Mahendararaj K, Hecht EM, Susman J, Weintraub JL, Chabot J.  Single institution experience with irreversible electroporation for T4 pancreatic cancer: first 50 patients.  Annals of Surgical Oncology.  2016;23: 1736-1743.  PMID: 26714959 Santambrogio R, Savino B, Kluger MD, Costa M, Salceda J, Belli A, Laurent A, Barabino M, Opocher E, Azoulay D, Cheraui D. Laparoscopic ablation therapies of hepatic resection in cirrhotic
About: 

Dr. Michael Kluger is board-certified in general surgery and specialty trained in liver and pancreas surgery. He focuses on the operative management of pancreatic cancer, liver cancer, gallbladder disease and metastases to the liver and abdominal peritoneum. These complex diseases require treatment plans tailored to each patient's needs; therefore Dr. Kluger employs a multidisciplinary approach to determine the best available treatment options that maximize survival and quality of life. He is highly skilled in minimally invasive procedures, and uses laparoscopy whenever indicated.

Dr. Kluger graduated from the New York University School of Medicine, where he was elected to the Alpha Omega Alpha medical honor society and received awards for bioethics and community service. He completed his surgical residency at NewYork-Presbyterian Hospital/Columbia University Medical Center. There he was selected to be the Administrative Chief Resident and won the Gold Foundation Humanism and Excellence in Teaching Award. He received advanced training in liver transplantation and hepatobiliary surgery at Hospital Henri Mondor in France under the world-renowned surgeon Professor Daniel Cherqui. He is a Fellow of the American College of Surgeons, and a member of several prestigious professional organizations, including the Society of Surgical Oncology and the Society for Surgery of the Alimentary Tract.