The Endocrine Surgery program at Columbia University is one of the premier sources of endocrine care, education, and innovation in the country. Our pioneering research continues to advance our understanding of endocrine diseases and improve the health of our patients. As a multidisciplinary center, we have several ongoing clinical trials, some of which are listed below. You may be asked by a member of our research team to consider participating in one of these studies if you are eligible. You may also ask our team about your eligibility for a study if you are interested in participating.
Current Trials
Quality of Life Measures After Treatment of Benign Thyroid Nodule
Study Investigators: Jennifer H. Kuo, MD MS (Primary), James A. Lee MD, Catherine McManus MD MS
Funding Source: ThyCA / American Thyroid Association
A prospective cohort study evaluating quality of life measures after RFA for benign multinodular goiter.
Who Qualifies?
- All adult patients >/=18 years of age who present to the Columbia Thyroid Center with benign symptomatic goiter will be eligible for enrollment.
What's Involved?
- Participants who elect to undergo RFA for treatment will be compared to those who elect observation or surgery.
Clinical Outcomes After Radiofrequency Ablation or Active Surveillance of Papillary Microcarcinoma
Study Investigators: Jennifer H. Kuo, MD MS (Primary), James A. Lee MD, Catherine McManus MD MS
Funding Source: ThyCA / American Thyroid Association
A single institution randomized controlled trial evaluating clinical outcomes after RFA vs active surveillance (AS) for papillary microcarcinoma (mPTC).
Who Qualifies?
- All adult patients >/=18 years of age with a biopsy proven papillary thyroid cancer =1.5cm who opt in for the active surveillance program at the Columbia Thyroid Center will be eligible for enrollment in the study.
Clinical Outcomes After Radiofrequency Ablation of Indeterminate (Bethesda III) Nodules, Classified Benign
Study Investigators: Jennifer H. Kuo, MD MS (Primary), James A. Lee MD, Catherine McManus MD MS
Funding Source: ThyCA / American Thyroid Association
A single institution prospective cohort study evaluating clinical outcomes after RFA for indeterminate thyroid nodules that have been molecular profiled benign.
Who Qualifies?
- All adult patients >/=18 years of age who present to the Columbia Thyroid Center with an indeterminate nodule demonstrating atypical cytology or follicular lesion of unknown significance (Bethesda III) that has been molecularly profiled as benign, will be eligible for enrollment in the study.
What's Involved?
- Participants who elect to undergo RFA for treatment will be compared to those who elect observation or surgery.
Assessment of Quality of Life for Patients with Primary Hyperparathyroidism
Study Investigators: Catherine McManus MD MS, (Primary), James A. Lee MD, Jennifer H. Kuo MD MS
A single institution prospective cohort study evaluating how primary hyperparathyroidism impacts quality of life, and more specifically determine what symptoms improve after surgery and to what degree.
Who Qualifies?
- All adult patients >/=18 years of age who present to the Columbia Parathyroid Center for treatment of primary hyperparathyroidism are eligible to participate.
What's Involved?
- The study consists of participating in three interviews(zoom or in person) ~30 minutes long to discuss your symptoms in depth: one prior to surgery and two postoperatively at 1 and 6 months.
Atenolol for the Prevention of Osteoporosis (APO) Study
Study Investigators: Marcella Walker MD, (Primary), James A. Lee MD, Jennifer H. Kuo MD MS, Catherine McManus MD MS
The goal of this study is to learn whether treatment with a safe, commonly used drug called ATENOLOL prevents bone loss in women after menopause.
Who Qualifies?
- Healthy post-menopausal women who are between the ages of 50 and 75.
- You may not be eligible if you have certain medical conditions.
What's Involved?
- If you are eligible, you will be assigned randomly to take a pill that may be either atenolol or a placebo.
- If you join this study, you will have 6 study visits to CUIMC over 2 years.
Visit Procedures Include:
- Measure heart rate and blood pressure.
- Questionnaires about health and diet.
- A DXA scan to measure Bone Density.
- A Bone Quality scan to measure strength of your wrist and ankle bones.
- A blood test for bone markers.
All tests will be free of charge. If you join, you will be compensated for your time and travel.
Please contact (212) 305-7225 or BoneResearch@cumc.columbia.edu if you are interested.
Sleep and Cognition in Primary Hyperparathyroidism
Study Investigators: Catherine McManus MD MS, (Primary), James A. Lee MD, Jennifer H. Kuo MD MS
This study looks at whether sleep quality, brain function, and mood improve after surgery in patients with primary hyperparathyroidism and certain types of thyroid disease
Who Qualifies?
-
Men and post-menopausal women (at least 2 years post-menopause) undergoing parathyroid or thyroid surgery and who speak English as a first language are eligible for this study.
What's Involved?
- The study consists of participating in three interviews(zoom or in person) and will require a noninvasive at home sleep apnea test, blood work, mood questionnaires, memory tests, and wearing a watch to monitor sleep at home.
Please contact (929) 265-8993 or da2902@cumc.columbia.edu if you are interested. Learn more about this study.