Physician’s Profile

Adam D. Griesemer, MD

Surgical Director, Pediatric Liver Transplantation
Surgical Director, Living Donor Liver Transplantation-Columbia Campus
Director, Large Animal Xenotransplantation Laboratory, Columbia Center for Translational Immunology
Affiliations: 
NewYork-Presbyterian/Columbia
Komansky Center for Children's Health
NewYork-Presbyterian/Morgan Stanley Children's Hospital
NewYork-Presbyterian/Weill Cornell
Contact Phone: 
(212) 305-9691
Board Certificates: 
Surgery
Expertise: 
Transplant Surgery
Pediatric Transplant Surgery
Portal Hypertension
Surgery
Minimally Invasive Surgery
Shunts
Living Donor Liver Surgery
Abdominal Organ Transplant, Pediatric
Abdominal Organ Transplantation
Liver Transplant
Liver Transplant, Pediatric
Living Donor Transplantation
Organ Transplant, Pediatric
Transplantation Surgery
Honors: 

Rising Star in Transplant Surgery, American Society of Transplant Surgery 2020

Faculty Development Grant, American Society of Transplant Surgeons, 2018

Nominated for Physician of the Year by Surgical Intensive Care Unit, 2017

AASLD Career Development Award in Liver Transplantation, 2015

Forde Award for Research, Columbia University, 2013

Department of Surgery's Chairman's Research Award, Columbia University College of Physicians and Surgeons, 2013

Louis V. Gerstner, Jr. Scholar – Research Award, Columbia University College of Physicians and Surgeons, 2013

Blakemore Prize - Best Resident Research Award, Columbia University College of Physicians and Surgeons, 2011

Blakemore Award - Best Resident Research Award, Columbia University College of Physicians and Surgeons, 2009

American Society of Transplantation Young Investigator Award, Transplantation Biology Research Center, Harvard Medical School, 2008

International Xenotransplantation Travel Grant, Transplantation Biology Research Center, Harvard Medical School, 2007

American Society of Transplantation/JDRF Research Fellowship Award, Transplantation Biology Research Center, Harvard Medical School, 2005

Alpha Omega Alpha, University of Missouri-Columbia School of Medicine, 2003

Marion DeWeese Award for Excellence in General Surgery, University of Missouri-Columbia School of Medicine, 2003

Donald Silver Award for Excellence in Vascular Surgery, University of Missouri-Columbia School of Medicine, 2003

Interests: 
Use of Tregs to control natural antibody responses and facilitate xenogeneic bone marrow engraftment
Xenogeneic tolerance induction via mixed chimerism and thymus transplant
Allogeneic tolerance induction
Control of humoral rejection
Small for Size Syndrome after Living Donor Liver Transplantation
Lab Members: 
Paula Alonso-Guallart, DVM, Postdoctoral Researcher
Karina Bruestle, MD, Postdoctoral Researcher
Hiroshi Sakai, MD, Postdoctoral Researcher
Emily Lopes, Lab Technician
Karl Erik Berglund, MD, Postdoctoral Researcher
Nathaly Llore, MD, Postdoctoral Researcher
Genevieve Pierre, Lab Technician
Publications: 
Alonso-Gullart P, Llore N, Lopes E, Kofman S, Ho S, Stern J, Pierre G, Bruestle K, Tang, Q, Sykes M, Griesemer A. CD40L-stimulated B cells for ex vivo expansion of polyspecific nonhuman primate regulatory T cells for translational studies. In Revision 2020. Clinical and Experimental Immunology. Duggan EM, Griesemer A. Progress towards xenogeneic tolerance. Current Opinion in Organ Transplantation 2020. In Press. Hozain AE, O’Neill JD, Pinezich MR, Tipograf U, Donocoff R, Cunningham KM, Tumen A, Fung K, Ukita R, Simpson M, Reimer JA, Ruiz EC, Queen D, Stokes JW, Cardwell NK, Talackine J, Snoeck H, Chen Y, Romanov, A, Marboe CC, Griesemer AD, Guenthart BA, Bacchetta M, Vunjak-Novakovic G. Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs. Nature Medicine. 2020 In press. Kato T, Hwang R, Liou P, Weiner J, Griesemer A, Samstein B, Halazun K, Mathur A, Schwartz G, Cherqui D, Emond J. Ex vivo resection and autotransplantation for conventionally unresectable tumors – an 11-year single center experience. Annals of Surgery. 2020. In Press. Heinz N, Griesemer A, Kinney J, Vittorio J, Lagana S, Golder D, Velasco M, Kato T, Lobritto S, Martinez M. A case of infant with SARS-CoV-2 hepatitis early after liver transplantation. Pediatric Transplantation. 2020. In press. Lagana SM, De Michele S, Lee MJ, Emond JC, Griesemer AD, Tulin-Silver SA, Verna EC, Martinez M, Lefkowitch JH. COVID-19 Associated Hepatitis Complicating Recent Living Donor Liver Transplantation. Archives of Pathology and Laboratory Medicine. 2020 Apr 17. PMID: 32302212 Chaudhry S, Kato Y, Weiner J, Alonso-Guallart P, Baker S, Woodland DC, Lefkowitch JH, Duran-Struuck R, Sondermeijer HP, Zitsman J, Sears ML, Wu A, Karolewski B, Houck PJ, Martinez M, Kato T, Sykes M, Griesemer AD. In contrast to kidney, liver allograft tolerance is not achieved with a transient mixed chimerism regimen in nonhuman primates. Transplantation. 2020 Apr 6. Epub ahead of print. PMID: 32265416 Winer L, Vivero M, Scully B, Cortez A, Kassam A, Nowygrod R, Griesemer A, Emond JE, Quillin R. Exploring medical students’ perceptions of organ procurement: Need for a formalized medical student curriculum. Journal of Surgical Education. J Surg Educ. 2019 Nov 18. PMID: 31753606 Sellberg F, Berglund D, Binder C, Hope J, Fontenot J, Griesemer A, Sykes M, Sachs DH, Berglund E. Pharmacokinetic and pharmacodynamic study of a clinically effective anti-CD2 monoclonal antibody. Scand J Immunol. 2019 Oct 20:e12839. PMID: 31630416 Berglund E, Alonso-Guallart P, Danton M, Sellberg F, Binder C, Fröbom R, Berglund D, Llore N, Sakai H, Iuga A, Ekanayake-Alper D, Reimann KA, Sachs DH, Sykes M, Griesemer A. Safety and pharmacodynamics of anti-CD2 monoclonal antibody treatment in cynomolgus macaques. Transpl Int. 2019 Sep 15. PMID: 31523849 Alonso-Guallart P, Duran-Struuck R, Zitsman J, Sameroff S, Pereira M, Stern J, Berglund E, Llore N, Pierre G, Lopes E, Kofman S, Danton M, Sondermeijer H, Woodland D, Kato Y, Ekanayake-Alper D, Iuga A,  Wuu CS, Wu A, Lipkin I, Tokarz R, Sykes M, Griesemer A. Impact of CMV reactivation and treatment approaches on the clinical course and immune reconstitution in a non-myeloablative tolerance induction protocol in Cynomolgus macaques. Transplantation. 2019 PMID: 31385931 Reis S, Bruestle K, Brejt S, Tulin-Silver S, Frenkel J, Mobley D, Griesemer A, England R, Sobolevsky S, Sperling D, Schlossberg P, Susman J, Weintraub J. Two-week interval biliary stricture dilation protocol may decrease biliary drainage time following pediatric liver transplant. Pediatric Transplantation 2019. In press. PMID: 31313460 Sykes M, Griesemer A. Transplantation tolerance in nonhuman primates and humans. Bone Marrow Transplant. 2019 Aug;54(Suppl 2):815-821. doi: 10.1038/s41409-019-0620-3. PMID: 31431694 Yu YD, Huang R, Halazun KJ, Griesemer A, Kato T, Emond J, Samstein B. Whose Liver Is It Anyway?: Two Centers Participating in One Living Donor Transplantation. Liver Transpl. 2019 Nov;25(11):1710-1713. PMID: 31273912 Hecht EM, Wang ZJ, Kambadakone A, Griesemer AD, Fowler KJ, Heimbach JK, Fider JL. Living Donor Liver Transplantation: Preoperative Planning and Postoperative Complications. AJR Am J Roentgenol. 2019 Apr 11:1-12. PMID: 30973784 Hecht EM, Kambadakone A, Griesemer AD, Fowler KJ, Wang ZJ, Heimbach JK, Fidler JL. Living Donor Liver Transplantation: Overview, Imaging Technique, and Diagnostic Considerations. AJR Am J Roentgenol. 2019 Apr 11:1-11. PMID: 30973783 Vittorio J, Orellana K, Martinez M, Ovchinsky N, Schlossberg P, Griesemer A, Lobritto S. Partial Splenic Embolization is a Safe and Effective Alternative in the Management of Portal Hypertension in Children. Journal of Pediatric Gastroenterology and Nutrition. 2019; PMID: 30908386 Chaudhry S, Emond JE, Griesemer A. Immune Cell Trafficking to the Liver. Transplantation. PMID: 30817405 Alonso-Guallart P, Zitsman JS, Stern J, Kofman SB, Woodland D, Ho SH, Sondermeijer HP, Bühler L, Griesemer A, Sykes M, Duran-Struuck R. Characterization, biology, and expansion of regulatory T cells in the Cynomolgus macaque for pre-clinical studies. Am J Transplant. 2019 Feb 15. PMID:30768842 Fu J, Zuber J, Martinez M, Shonts B, Obradovic A, Wang H, Lau SP, Xia A, Waffarn EE, Frangaj K, Savage TM, Simpson MT, Yang S, Guo XV, Miron M, Senda T, Rogers K, Rahman A, Ho SH, Shen Y, Griesemer A, Farber DL, Kato T, Sykes M. Human Intestinal Allografts Contain Functional Hematopoietic Stem and Progenitor Cells that Are Maintained by a Circulating Pool. Cell Stem Cell. 2018 Nov 21 PMID: 30503142  Llore NP, Bruestle KA, Griesemer A. Xenotransplantation tolerance: applications for recent advances in modified swine. Curr Opin Organ Transplant. 2018 Dec;23(6):642-648. PMID: 30379724 PMC7010353 Samstein B, Griesemer A, Halazun K, Kato T, Guarrera JV, Cherqui D, Emond JC. Pure Laparoscopic Donor Hepatectomies: Ready for Widespread Adoption? Ann Surg. 2018 Aug 10. PMID: 30102634 Chaudhry SG, Bentley-Hibbert S, Stern J, Lobritto S, Martinez M, Vittorio J, Halazun KJ, Lee HT, Emond J, Kato T, Samstein B, Griesemer A. Growth of Liver Allografts Over Time in Pediatric Transplant Recipients. Pediatric Transplantation. 2018 Mar;22(2). PMID: 29334158 Elnaggar AS, Griesemer AD, Bentley-Hibbert S, Brown RS, Martinez M, Lobritto SJ, Kato T, Emond JC. Liver Atrophy and Regeneration in Non-Cirrhotic Portal Vein Thrombosis: Effect of Surgical Shunts. Liver Transplantation. 2018 Jul;24(7):881-887. PMID: 29377486 Quillin RC, Bongu A, Kasper v, Vittorio JM, Martinez M, Lobritto SJ, Griesemer AD, Guarrera JG. Roux-en-Y enterolith leading to obstruction and ischemic necrosis after pediatric orthoscopic liver transplantation. Pediatric Transplantation. 2018. In 2018 May;22(3):e13160. PMID: 29607581 Przybyszewski EM, Verna EC, Lobritto SJ, Martinez M, Vittorio J, Fox AN, Samstein B, Kato T, Griesemer AD, Emond JC. Durable Clinical and Immunologic Advantage of Living Donor Liver Transplantation in Children. Transplantation 2018. Jun;102(6):953-960. PMID: 29369249 Vallabhajosyula P, Hirakata A, Weiss M, Griesemer A, Shimizu A, Hong H, Habertheuer A, Tchipashvili V, Yamada K, Sachs DH. Effect of the Diabetic State on Islet Engraftment and Function in a Large Animal Model of Islet-Kidney Transplantation. Cell Transplant. 2017 Nov;26(11):1755-1762. PMID: 29338381 Rahnemai-Azar AA, Griesemer AD, Velasco ML, Kato T. Ex vivo excision of retroperitoneal soft tissue tumors: A case report. Oncol Lett. 2017 Oct;14(4):4863-4865. PMID: 29085493 Kato Y, Griesemer AD, Wu A, Sondermeijer H, Weiner JI, Duran-Struuck R, Martinez M, Slate A, Romanov A, Lefkowitch JH, Sykes M, and Kato T. Novel H-Shunt Venovenous Bypass for Liver Transplantation in Cynomolgus Macaques. Comparative Medicine. 2017 Oct 1;67(5):436-441. PMID: 28935006 Halazun KJ, Rana AA, Fortune B, Quillan RC, Verna EC, Samstein B, Guarrera JV, Kato T, Griesemer AD, Fox A, Brown RS Jr, Emond JC. No Country for Old Livers? Examining and Optimizing the Utilization of Elderly Liver Grafts. Am J Transplant. 2017 Sep 27.  PMID: 28960723 Carpenter DJ, Granot T, Matsuoka N, Senda T, Kumar BV, Thome JJC, Gordon CL, Miron M, Weiner J, Connors T, Lerner H, Friedman A, Kato T, Griesemer AD, Farber DL. Human immunology studies using organ donors: impact of clinical variations on immune parameters in tissues and circulation. Am J Transplant. 2017 Jul 18. PMID: 28719147 Halazun KJ, Quillin RC, Rosenblatt R, Bongu A, Griesemer AD, Kato T, Smith C, Michelassi F, Guarrera JV, Samstein B, Brown RS Jr, Emond JC. Expanding the Margins: High Volume Utilization of Marginal Liver Grafts Among >2000 Liver Transplants at a Single Institution. Ann Surg. 2017 Jun 27. PMID: 28657945. Griesemer AD, Emond JC. Big improvements for the smallest recipients. Liver Transpl. 2017 Jun 15. PMID: 28618184. Granot T, Senda T, Carpenter DJ, Matsuoka N, Weiner J, Gordon CL, Miron M, Kumar B, Griesemer A, Ho S, Lerner H, Thome J, Connors T, Reizis B, Farber DL. Dendritic cells display subset and tissue-specific maturation dynamics over human life. Immunity. 2017 Mar 21;46(3):504-515.  Duran-Struuck R, Sondermeijer HP, Bühler L, Alonso-Guallart P, Zitsman J, Kato Y, Wu A, McMurchy AN, Woodland D, Griesemer A, Martinez M, Boskovic S, Kawai T, Cosimi AB, Wuu CS, Slate A, Mapara M, Baker S, Tokarz R, Dʼ Agati V, Hammer S, Pereira M, Lipkin WI, Wekerle T, Levings M, Sykes M. Effect of ex vivo Expanded Recipient Regulatory T Cells on Hematopoietic Chimerism and Kidney Allograft Tolerance Across MHC Barriers in Cynomolgus Macaques. Transplantation. 2017 Eeb;101(2):274-283. PMID: 27846155 Halazun KJ, Najjar M, Abdelmessih RM, Samstein B, Griesemer AD, Guarrera JV, Kato T, Verna EC, Emond JC, Brown RS Jr. Recurrence After Liver Transplantation for Hepatocellular Carcinoma: A New MORAL to the Story. Ann Surg. 2016 Sep 16. PMID: 27611615 Emond JC, Griesemer AD. Tolerance in clinical liver transplantation: The long road ahead. Hepatology 2017 Feb;65(2):411-413.  PMID: 27718261 Zuber J, Shonts B, Lau S, Obradovic A, Fu J, Yang S, Lambert M, Coley S, Weiner J, Thome J, DeWolf S, Farber DL, Shen Y, Caillat-Zucman S, Bhagat G, Griesemer A, Martinez M, Kato T, Sykes M. Bidirectional intragraft alloreactivity drives the repopulation of human intestinal allografts and correlates with clinical outcome. Science Immunology. 2016 October 07; 1(4). Halazun KJ, Przybyszewski EM, Griesemer AD, Cherqui D, Michelassi F, Guarrera JV, Kato T, Brown RS Jr, Emond JC, Samstein B. Leaning to the Left: Increasing the Donor Pool by Using the Left Lobe, Outcomes of the Largest Single-center